FIG. 7.

Metformin improves clinical symptoms in patients with FM after 1 month of treatment. n=6 patients were treated with metformin. Clinical response of the patients after treatment by FIQ total score punctuation (A), several subitems from the FIQ as pain, fatigue, morning tiredness, stiffness, and depression (B), tender points (C), VAS about pain (D), fatigue (E), BDI (F), PSQI (G), and VAS sleep quality (H). Data represent the mean±SD.*p<0.001 between before and after metformin treatment in patients with FM. **p<0.01 between before and after metformin treatment in patients with FM. ***p<0.05 between before and after metformin treatment in patients with FM. BDI, Beck Depression Inventory; FIQ, Fibromyalgia Impact Questionnaire; PSQI, Pittsburgh Sleep Quality Index; VAS, visual analogue scale.