Table 2.
Genotypes and Allele Distributions in Patients with Coronary Heart Disease and Control Participants
| Total | Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CHD | Control | p | CHD | Control | p | CHD | Control | p | |
| Han population | |||||||||
| N | 331 | 404 | 211 | 208 | 120 | 196 | |||
| rs12050772 | |||||||||
| Allele | |||||||||
| G | 331 (0.500) | 358 (0.444) | 0.034 | 210 (0.498) | 187 (0.452) | 0.1836 | 121 (0.504) | 171 (0.436) | 0.096 |
| T | 331 (0.500) | 448 (0.556) | 212 (0.502) | 227 (0.548) | 119 (0.496) | 221 (0.564) | |||
| Genotype | |||||||||
| GG | 82 (0.248) | 75 (0.186) | 54 (0.256) | 40 (0.193) | 28 (0.233) | 35 (0.179) | |||
| GT | 167 (0.505) | 208 (0.516) | 0.0852 | 102 (0.483) | 107 (0.517) | 0.3037 | 65 (0.542) | 101 (0.515) | 0.2236 |
| TT | 82 (0.248) | 120 (0.298) | 55 (0.261) | 60 (0.290) | 27 (0.225) | 60 (0.306) | |||
| rs2289105 | |||||||||
| Allele | |||||||||
| C | 384 (0.584) | 401 (0.498) | 0.001 | 242 (0.579) | 176 (0.421) | 0.2223 | 142 (0.592) | 194 (0.495) | 0.0189 |
| T | 274 (0.416) | 405 (0.502) | 207 (0.500) | 207 (0.500) | 98 (0.408) | 198 (0.505) | |||
| Genotype | |||||||||
| CC | 114 (0.347) | 93 (0.231) | 70 (0.335) | 45 (0.217) | 44 (0.367) | 48 (0.245) | |||
| CT | 156 (0.474) | 215 (0.533) | 0.0019 | 102 (0.488) | 117 (0.565) | 0.027 | 54 (0.450) | 98 (0.500) | 0.053 |
| TT | 59 (0.179) | 95 (0.236) | 37 (0.177) | 45 (0.217) | 22 (0.183) | 50 (0.255) | |||
| Paired comparisons | |||||||||
| CC/CT | 0.0198 | 0.013 | |||||||
| CC/TT | 0.0016 | 0.0287 | |||||||
| rs4774585 | |||||||||
| Allele | |||||||||
| A | 9 (0.014) | 18 (0.022) | 0.2233 | 6 (0.014) | 10 (0.024) | 0.3081 | 3 (0.013) | 8 (0.020) | 0.4607 |
| G | 649 (0.986) | 790 (0.978) | 412 (0.986) | 406 (0.976) | 237 (0.988) | 384 (0.980) | |||
| Genotype | |||||||||
| AA | |||||||||
| AG | 9 (0.027) | 18 (0.045) | 0.2189 | 6 (0.029) | 10 (0.048) | 0.3033 | 3 (0.025) | 8 (0.041) | 0.4567 |
| GG | 320 (0.973) | 386 (0.955) | 203 (0.971) | 198 (0.952) | 117 (0.975) | 188 (0.959) | |||
| Uygur population | |||||||||
| N | 591 | 312 | 337 | 187 | 254 | 153 | |||
| rs12050772 | |||||||||
| Allele | |||||||||
| G | 465 (0.395) | 247 (0.396) | 0.9639 | 277 (0.411) | 153 (0.409) | 0.9525 | 188 (0.373) | 118 (0.386) | 0.7198 |
| T | 713 (0.605) | 377 (0.604) | 397 (0.589) | 221 (0.591) | 316 (0.627) | 188 (0.614) | |||
| Genotype | |||||||||
| GG | 96 (0.163) | 42 (0.135) | 58 (0.172) | 25 (0.134) | 38 (0.151) | 21 (0.137) | |||
| GT | 273 (0.463) | 163 (0.522) | 0.2165 | 161 (0.478) | 103 (0.551) | 0.244 | 112 (0.444) | 76 (0.497) | 0.5925 |
| TT | 220 (0.374) | 107 (0.343) | 118 (0.350) | 59 (0.316) | 102 (0.405) | 56 (0.366) | |||
| rs2289105 | |||||||||
| Allele | |||||||||
| C | 561 (0.478) | 291 (0.468) | 0.6861 | 321 (0.476) | 178 (0.478) | 0.9448 | 240 (0.480) | 143 (0.467) | 0.7264 |
| T | 613 (0.522) | 331 (0.532) | 353 (0.524) | 194 (0.522) | 260 (0.520) | 163 (0.533) | |||
| Genotype | |||||||||
| CC | 140 (0.239) | 62 (0.199) | 80 (0.237) | 36 (0.194) | 60 (0.240) | 33 (0.216) | |||
| CT | 281 (0.479) | 167 (0.537) | 0.219 | 161 (0.478) | 106 (0.570) | 0.1303 | 120 (0.480) | 77 (0.503) | 0.84 |
| TT | 166 (0.283) | 82 (0.264) | 96 (0.285) | 44 (0.237) | 70 (0.280) | 43 (0.281) | |||
| rs4774585 | |||||||||
| Allele | |||||||||
| A | 134 (0.114) | 59 (0.095) | 0.2179 | 62 (0.092) | 43 (0.116) | 0.224 | 72 (0.143) | 20 (0.065) | 0.0008 |
| G | 1044 (0.886) | 563 (0.905) | 612 (0.908) | 329 (0.884) | 432 (0.857) | 286 (0.935) | |||
| Genotype | |||||||||
| AA | 5 (0.008) | 6 (0.019) | 1 (0.003) | 5 (0.027) | 4 (0.016) | 1 (0.007) | |||
| AG | 124 (0.211) | 47 (0.151) | 0.0424 | 60 (0.178) | 33 (0.177) | 0.0485 | 64 (0.254) | 18 (0.118) | 0.0025 |
| GG | 460 (0.781) | 258 (0.830) | 276 (0.819) | 148 (0.796) | 184 (0.730) | 134 (0.876) | |||
| Paired comparisons | |||||||||
| GG/AG | 0.0355 | 0.9157 | 0.001 | ||||||
| GG/AA | 0.2025 | 0.0139 | 0.3193 | ||||||
p values were calculated by χ2 test or Fisher exact test.
p < 0.05.