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. 2016 Feb 1;5(2):79–88. doi: 10.1089/wound.2014.0600

Table 2.

Comparison of local versus systemic drug delivery

Systemic delivery Local delivery
IV injection/oral route Direct delivery to the wound site
Risk of multi-organ toxicity Enables sustained drug administration
Less predictable Skin irritation
Requires higher dosing to achieve therapeutic effect Avoidance of hepatic first-pass metabolism and the GI tract