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. 2016 Feb 4;7:10587. doi: 10.1038/ncomms10587

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(a) Sharpened map segmented and coloured according to complement proteins: C5b (tan), C6 (green), C7 (yellow), C8α (magenta), C8β (dark blue), C8γ (orange) and C9 (light blue). CDC/MACPF β-barrel and detergent belt are in grey colour. Density is overlaid on the unsharpened map (transparent surface). Axes are shown. (b) Fitting of the C5b6 crystal structure into a cross-section of the unsharpened map (grey surface). C5b and C6 are in grey colour and green ribbons, respectively. (c) ‘Split-washer' configuration of the MAC comprises 4 asymmetric (orange) and 18 symmetric (blue) staves. Incomplete membrane penetration of the β-barrel is indicated (arrow). (d) Reference-free aligned class average corresponding to a top view of the MAC (left panel) and representative raw images belonging to this class (middle panel), clearly showing the ‘split-washer' shape of the rim. Cartoon schematic illustrating the location of C6 and the last C9 molecule in the previous images (right panel).