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. 2016 Feb 1;30(3):257–265. doi: 10.1101/gad.274928.115

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© 2016 Patel et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — The non-A alleles of hPRDM9. (A) From hPRDM9_A, a single amino acid substitution at ZnF10 and ZnF11 resulted in alleles L9/L24, L20, or L13, respectively. (B) Comparison of DNA-binding affinities by different alleles (in the context of ZnF8–12) with the oligo containing the hot spot THE1B sequence. (C) A single base pair change at THE1B (from T:A to C:G) resulted in stronger binding by the N789H variant (allele L20). (D,E) Comparison of DNA-binding affinities by different alleles (in the context of ZnF8–12) with oligos containing hot spot sequences (MSTM1a and MSTM1b).