Table 1. Overview of Variables and Values.

Variable	Base Case		High		Low		Reference
Intervention Costs (per year):	$145,000.00		$217,500.00		$72,500.00		Waters16
	CLABSI	VAP	CLABSI	VAP	CLABSI	VAP
	Base Case	Base Case					Reference
Index ICU Stay:
Device Days
Usual care comparator	3324	2918	-	-	-	-	NNIS 200417
Multifaceted infection prevention program	2846	2028	4269	3042	1423	1014	NHSN 201118
Incidence (per 1000 device days)
Usual care comparator	5.0	4.9	-	-	-	-	NNIS 200417
Multifaceted infection prevention program	1.2	1.1	4.8	4.7	0.0	0.0	NHSN 201118
Attributable Death Rate	0.160	0.103	0.250	0.161	0.120	0.077	Eber3
Costs
Inpatient $ / HAI case	$16,155.00	$21,163.00	$24,232.50	$31,744.50	$8,077.50	$10,581.50	CDC2
	Base Case		High		Low		Reference
Post-index ICU stay experiences:
Discount rate	3%		5%		0%
Quality of life decrements
Hospital admission*	0.121		0.182		0.061		Scherbaum30
Home care day**	0.570		0.855		0.285
Long-term care day**	0.570		0.855		0.285
Emergency room visit day**	0.400		0.600		0.200
Age 65***			0.200
Age > 65 / per year***			0.005				Wagner31
Costs
Hospital day	$2,048.36		$3,072.54		$1,024.18
Home care day	$143.83		$215.75		$71.92
Emergency room visit	$5,655.57		$8,483.36		$2,827.79
Long-term care day	$99.54		$149.30		$49.77

^*The hospital admission utility decrement is an annual decrement

^**The home care, long-term care, and emergency room decrements are per day

^***We apply an age-based decrement to utility, setting QALY to 0.80 at age 65 and decreasing by 0.005 per year thereafter (See Wagner³¹).

CLABSI: Central Line-Associated Bloodstream Infections, HAI: Healthcare-Associated Infections, ICU: Intensive Care Unit, QALY: Quality-Adjusted Life Years, VAP: Ventilator-Associated Pneumonia