Fig. 5.

Collagen gel contraction assay of IPF derived cells from two different patients are shown (a and b). The values shown are gel sizes compared to the original size. Averages of relative gel sizes related to the corresponding control at each time point of samples derived from seven patients with IPF (c). Relative values from four cell lines treated with TGFβ1 alone, TGFβ1 and pirfenidone or TGFβ1 and nintedanib (d). The concentrations used were 5 ng/ml TGFβ1, 0.5 mM pirfenidone and 0.5 μM nintedanib