Table 1.
Demographic characteristics and risk factors for patients with acquired drug resistant TB during SCC
| Characteristics | Pan-susceptible TB throughouta n = 1609(%) | Any acquired drug resistant TBb | Acquired MDR-TB vs. Pan-susceptible TB throughout | Acquired Non- MDR-TB vs. Pan-susceptible TB throughout | |||
|---|---|---|---|---|---|---|---|
| MDR-TBc n = 17(%) | Non-MDR-TBd n = 45(%) | OR (95 % CI)e | P value | OR(95 % CI) | P value | ||
| Age(years) | |||||||
| <40 | 756(47.0) | 1(5.9) | 19(42.2) | Reference | Reference | ||
| 40–59 | 560(34.8) | 13(76.5) | 20(44.5) | 17.5(2.3–134.6) | <0.001 | 1.4(0.8–2.7) | 0.278 |
| ≥60 | 293(18.2) | 3(17.6) | 6(13.3) | 7.7(0.8–74.7) | 0.07g | 0.8(0.3–2.1) | 0.665 |
| Gender | |||||||
| Male | 1160(72.1) | 14(82.4) | 35(77.8) | Reference | Reference | ||
| Female | 449(27.9) | 3(17.6) | 10(22.2) | 0.6(0.2–1.9) | 0.427g | 0.7 (0.4–1.5) | 0.401 |
| BMIf (Kg/m2) | |||||||
| BMI < 18.5 | 620(38.5) | 3(17.6) | 18(40.0) | Reference | Reference | ||
| BMI ≥ 18.5 | 989(61.5) | 14(82.4) | 27(60.0) | 2.9(0.8–10.2) | 0.078 | 0.9(0.5–1.7) | 0.842 |
| Treatment history | |||||||
| New | 1407(87.4) | 11(64.7) | 38(84.4) | Reference | Reference | ||
| Previously treated | 202(12.6) | 6(35.3) | 7(15.6) | 3.8(1.4–10.4) | 0.015g | 1.3(0.6–2.9) | 0.550 |
aPan-susceptible TB throughout in our study was defined as cases with TB strains susceptible to all four first-line anti-TB drugs including soniazid(H), rifampicin(R), ethambutol(E), and streptomycin(S) both pretreatment and throughout therapy
bAny acquired drug resistant TB in our study was defined as cases with TB strains that were susceptible to all four first-line anti-TB drugs pretreatment, but developed resistance to at least one of the four drugs during SCC
c MDR-TB was defined as TB that was at least resistant to both isoniazid and rifampicin
dNon-MDR-TB in our study was defined as TB cases with any drug resistance pattern except MDR-TB
eOR, odds ratio. CI, confidence interval
fBMI, body mass index, calculated as the weight in kilograms divided by the square of the height in meters
g P value was determined by Fisher’s Exact Test. Not indicated was determined by Pearson’s Chi-Square Test