Table 2.
Outcomes of singleton pregnancies with LPV/r exposure (n=4762)
| Total live births, n (%) | 4556 (95.7) |
| ᅟConception on LPV/r, n | 863 |
| ᅟInitiation of LPV/r, n | 3693 |
| Mode of delivery, n (%) | n=4541 |
| ᅟVaginal delivery | 1664 (36.6) |
| ᅟElective caesarean delivery | 1776 (39.1) |
| ᅟEmergency caesarean delivery | 1101 (24.3) |
| Gestational age | n=4556 |
| ᅟMedian (IQR), wk | 38 (38–39) |
| ᅟ<32 wk, n (%) | 112 (2.5) |
| ᅟ32–36 wk, n (%) | 473 (10.4) |
| ᅟ≥37 wk, n (%) | 3971 (87.2) |
| Birth weight | n=4395 |
| ᅟMedian (IQR), g | 3030 (2710–3360) |
| ᅟ<1500 g, n (%) | 101 (2.3) |
| ᅟ1500–2499 g, n (%) | 545 (12.4) |
| ᅟ≥2500 g, n (%) | 3749 (85.3) |
| Infant mortality, n | 24 |
| ᅟRate by gestational age | |
| ᅟᅟ<32 wk, n/N, per 1000 infants (95 % CI) | 14/112, 125.0 per 1000 infants (62.8–187.2) |
| ᅟᅟ32–36 wk, n/N, per 1000 infants (95 % CI) | 4/473, 8.5 per 1000 infants (0.2–16.7) |
| ᅟᅟTerm, n/N, per 1000 infants (95 % CI) | 6/3971, 1.5 per 1000 infants (0.3–2.7) |
| Stillbirth, n (%) | 44 (0.9) |
| ᅟConception on LPV/r, n/N (%) | 7/952 (0.7) |
| ᅟInitiation of LPV/r, n/N (%) | 37/3810 (1.0) |
| ᅟRate by gestational age | |
| ᅟᅟ<32 wk, n/N, per 1000 infants (95 % CI) | 23/135, 170.4 per 1000 infants (106.1–234.6) |
| ᅟᅟ32–36 wk, n/N, per 1000 infants (95 % CI) | 8/481, 16.6 per 1000 infants (5.2–28.1) |
| ᅟᅟTerm, n/N, per 1000 infants (95 % CI) | 13/3984, 3.3 per 1000 infants (1.5–5.0) |
| Miscarriage or termination,a n (%) | 120 (2.5) |
| ᅟConception on LPV/r, n/N (%) | 76/952 (8.0) |
| ᅟInitiation of LPV/r, n/N (%) | 44/3810 (1.2) |
| Left United Kingdom/Ireland before delivery, n (%) | 42 (0.9) |
Abbreviations: LPV/r lopinavir/ritonavir, IQR interquartile range
aBased on data reported from antenatal care providers