Table 1.
Serial transmission of MM2-cortical sCJD to mice expressing human or ovine PrP
| Inoculum | Passage | Mean incubation timeb (n/n0) | |
|---|---|---|---|
| tg650 (human PrP) | tg338 (ovine PrP) | ||
| MM2-sCJD | 1 | 278 ± 6 (6/6) | 557 ± 11 (6/7) |
| 2 | 274 ± 4 (8/8) | 84 ± 1 (6/6) | |
| 3 | 280 ± 4 (12/12) | 81 ± 2 (6/6) | |
| 4 | 268 ± 4 (8/8)a | 78 ± 2 (7/7) | |
| 5 | nd | 80 ± 1 (6/6) | |
n/n0: number of mice with neurological disease and positive for PrPres in the brain by immunoblotting/number of inoculated mice
aSubpassage after cloning by end-point titration
bDays ± SE of the mean.
nd: not done