Table 4.

Endpoint titration of isolated T1^Ov and T2^Ov MM2-sCJD prions in ovine PrP mice

Inoculum	Dilution	Mean incubation timea (n/n0)
		T2Ov b	T1Ov b
MM2-sCJD	10−4	142 ± 8 (5/5)	nd
	10−5	146 (1/6)	148 ± 4 (6/6)
	10−6	174; 192 (2/6)c	212 ± 6 (3/6)c
	10−7	> 450 (0/6)c	> 450 (0/6)c
	10−8	>450 (0/6)c	> 450 (0/6)c

n/n₀: number of mice with neurological disease and positive for PrP^res in the brain by immunoblotting/number of inoculated mice

^aDays ± SE of the mean.

^bThe T2^Ov and T1^Ov brain material were from tg338-cloned MM2-sCJD prions and from PMCA MM2-sCJD prions, respectively.

^congoing experiment

nd: not done