Table 3.

Univariate analysis of treatment-related parameters predicting late bowel toxicity

Variables	Strata (n)	Grade ≥II, absent	Grade ≥II, present	p-value	Grade ≥III, absent	Grade ≥III, present	p-value
Age (years)	<48	36	9	0.45	42	3	1.0
	≥48	36	6		39	3
Type of hysterectomy	Wertheim's	33	6	0.60	60	4	1.0
	Simple	51	13		36	3
Type of RT	IMRT	44	5	0.02	49	0	0.002
	3D CRT	23	10		27	6
Concurrent chemotherapy	Yes	72	15	0.48	81	6	1.0
	No	12	4		15	1
Body mass index (kg m−2)	<25	37	11	0.07	45	3	1.0
	≥25	35	4		36	3
Abdominal surgery	Single	59	13	0.25	66	6	0.72
	Multiple	3	2		5	0
Co-morbidities	Yes	9	3	0.69	10	2	0.18
	No	75	16		86	5
Tobacco use	Yes	14	1	0.29	14	1	0.98
	No	70	18		82	6
Acute grade II	Yes	48	15	0.11	56	7	0.04
	No	36	4		40	0
Acute grade III	Yes	12	8	0.01	14	6	0.0001
	No	72	11		82	1
V15 SB (cm3)	≥275	15	6	0.21	18	3	0.14
	<275	69	13		78	4
V30 SB (cm3)	≥190	16	9	0.01	21	4	0.05
	<190	68	10		75	3
V40 SB (cm3)	≥150	16	8	0.06	19	5	0.07
	<150	68	11		77	2
V15 LB (cm3)	≥250	8	5	0.06	9	4	0.005
	<250	76	14		87	3
V30 LB (cm3)	≥100	25	9	0.17	30	4	0.21
	<100	59	10		66	3
V40 LB (cm3)	≥90	20	8	0.15	24	4	0.08
	<90	64	11		72	3
V15 TB (cm3)	≥450	18	7	0.23	22	3	0.35
	<450	66	12		74	4
V30 TB (cm3)	≥330	13	6	0.11	16	3	0.11
	<330	71	13		80	4
V40 TB (cm3)	≥280	12	6	0.09	14	4	0.01
	<280	72	13		82	3
V15 PC (cm3)	≥1200	33	9	0.60	40	2	0.69
	<1200	51	10		56	5
V30 PC (cm3)	≥900	21	9	0.05	25	5	0.02
	<900	63	10		71	2
V40 PC (cm3)	≥750	12	9	0.003	16	5	0.004
	<750	72	10		80	2

3D CRT, three-dimensional conformal radiation; IMRT, intensity-modulated radiotherapy; LB, large bowel; PC, peritoneal cavity; RT, radiotherapy; SB, small bowel; TB, total bowel; V₁₅–V₄₀, volume of bowel getting the specified dose in gray.