Table 4.

Predictors of Overall Survival: Results of Multivariate Analysis

Variables	N	Median Survival (mo,(95%CI))	One Year Overall Survival (%)	p Univariate	Multivariate*	Hazard Ratio (95%CI)
Gender
Male	157	6.1 (3,9)	41	0.39
Female	33	4.9 (2,8)	31
Age (years)
≤ 60	145	6.3 (2,10)	43	0.02	0.01	1.7 (1,3)
> 60	45	3.8 (2,6)	27
Race/ethnicity
White	44	11.4 (3.8,18)	50	0.52
Black	82	4.7 (3,6)	34
Hispanic	54	7.7 (3,12)	41
Asian	10	2.8 (0,11)	38
Insurance
Yes	162	7.4 (4.2,11)	43	<0.01
None	28	2.7 (2,4)	14
Etiology of chronic liver disease
HCV alone	39	4.4 (2.5,6.1)	32	0.18
HBV alone	13	9.6 (0,25)	46
Alcohol alone	17	7.7 (3,13)	39
HCV/Alcohol	99	6.0 (2,10)	42
HBV/Alcohol	8	23.5 (0,58)	13
NASH	7	5.3 (1,9)	57
Other	7	5.3 (3,7)	38
Symptoms
Present	111	2.8 (2,3)	18
Absent	79	21.3 (13,29)	67	<0.01	<0.01	2.1 (1,3)
Child-Pugh-Turcotte
A	68	16.6 (7,26)	57	<0.01	<0.01	1.6 (1,2)
B	74	4.3 (1,8)	36
C	48	1.8 (1,3)	17
Number of tumors
Solitary	83	16.5 (3,30)	57	<0.01
Multiple	107	3.7 (2,9)	26
BCLC
A	38	25.7 (25,39)	75	<0.01
B	16	19.6 (10,29)	68
C	82	4.5 (3,6)	31
D	54	1.9 (1,3)	15
Treatment
Curative	17	NR	88	<0.01	<0.01	2.9 (2,4)
Locoregional	50	24.6 (20,29)	73
Systemic	10	5.9 (3,9)	40
None	113	2.6 (2,3)	16
Screening US one year prior to HCC diagnosis
Completed	35	12.5 (0,25)	50	0.25
Not done	155	4.9 (4,6)	37
More than 2 visits to primary care physician within 2 years of HCC diagnosis
Yes	97	12.1 (6,18)	50	0.01
No	93	3.3 (2,5)	27
HIV serostatus
Positive	26	9.6 (1,18)	40	0.85
Negative	164	5.2 (4,7)	38

^*Results of the multivariate analysis shown only for significant variables.

NR indicates not reached.