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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Circ Heart Fail. 2016 Feb;9(2):e002206. doi: 10.1161/CIRCHEARTFAILURE.115.002206

Figure 1.

Figure 1

Top: Change Δ (treatment effect) between pre-treatment and 2 hour intravenous infusion of elamipretide on left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF) and stroke volume (SV) in untreated heart failure control dogs (HF-CON) and heart failure dogs treated with elamipretide (HF+ELA). Bottom: Change Δ (treatment effect) between pre-treatment and 12 weeks post-treatment for LV EDV, ESV, EF and fractional area of shortening (FAS) in HF-CON and HF+ELA dogs. Probability values are comparisons between HF-CON and HF+ELA dogs. Statistical significance based on t-statistic for two means. All bar graphs are depicted as Mean±SEM.