Bar graphs (Mean±SEM) depicting protein levels of endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), peroxisome proliferator-activated receptor coactivator-1α (PGC-1α), cytosolic cytochrome c, active caspase 3 and sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA-2a) in LV myocardium of normal dogs (NL), untreated ailure control dogs (HF-CON) and heart failure dogs treated with elamipretide (HF+ELA). Below each graph, are bands from Western Blots of each protein. du=densitometric units. Statistical significance based on one way ANOVA followed by the Student-Neuman-Keuls.