TABLE 1.
Hemodynamic, ventriculographic, echocardiographic and plasma biomarker measures in untreated heart failure control dogs (HF-CON) (n=7) and heart failure dogs treated with elamipretide (HF+ELA) (n=7).
| HF-CON | HF+ELA | |||||
|---|---|---|---|---|---|---|
| Baseline | Pre-treatment | Post-treatment | Baseline | Pre-treatment | Post-treatment | |
| Body Weight (kg) | 22.7±0.7 | 23.1±0.7 | 24.0±0.5 | 21.5±0.4 | 22.1±0.4 | 23.0±0.7 |
| HR (beats/min) | 86±2 | 88±2 | 84±1 | 90±3 | 82±2* | 84±3 |
| mAoP (mmHg) | 72±1 | 74±1 | 74±1 | 75±1 | 73±2 | 71±1 |
| LVEDP (mmHg) | 12±1 | 15±1* | 16±1* | 12±1 | 17±1* | 14±0.3*† |
| LVEDV (ml) | 57±3 | 63±3 | 69±5* | 62±2 | 75±4* | 77±3* |
| LVESV (ml) | 28±1 | 44±3* | 48±4* | 32±1 | 52±2* | 49±2* |
| LVEF (%) | 51±1 | 31±1* | 29±1* | 49±1 | 30±2* | 36±2*† |
| SV (ml) | 29±2 | 19±1* | 21±2* | 31±1 | 23±2* | 28±2† |
| CO (L/min) | 2.5±0.16 | 1.7±0.11* | 1.76±0.15* | 2.73±0.08 | 1.86±0.14* | 2.34±0.11*† |
| CI (L/min/m2) | 3.2±0.2 | 2.1±0.1* | 2.1±0.2* | 3.3±0.1 | 2.2±0.2* | 2.8±0.1*† |
| SVR (dynes-sec-cm−5) | 2809±156 | 4223±232* | 3855±274* | 2642±105 | 3647±326* | 2916±167† |
| Ei/Ai | 7.5±0.9 | 4.5±0.4* | 4.2±0.3* | 7.3±1.0 | 4.8±0.6* | 5.3±0.6* |
| DT (msec) | 102±2 | 79±4* | 73±5* | 102±4 | 75±5* | 84±4* |
| LV EDWS (gm/cm2) | 46±2 | 77±3* | 78±9* | 47±3 | 87±9* | 69±7*† |
| nt-Pro BNP (pg/ml) | 262±15 | 1163±126* | 1250±113* | 278±17 | 1128±72* | 354±29*† |
| TNF-α (pg/ml) | 1.29±0.14 | 3.85±0.16* | 3.95±0.23* | 1.24±0.13 | 4.36±0.09* | 1.44±0.09† |
| IL-6 (pg/ml) | 9.1±2.3 | 24.9±2.1* | 28.6±1.9*† | 10.1±1.1 | 26.6±2.2* | 12.0±0.3*† |
| CRP (μg/ml) | 1.30±0.16 | 7.38±0.65* | 8.99±1.36* | 1.69±0.19 | 6.89±0.70* | 1.72±0.29† |
| Plasma ROS (RLUx105/ml) | 5.0±0.3 | 21.1±3.1* | 23.8±2.0* | 5.3±0.5 | 20.7±2.6* | 10.5±0.8*† |
HR=heart rate; mAoP=mean aortic pressure; LV=left ventricular; EDP=end-diastolic pressure; EDV=end-diastolic volume; ESV=end-systolic volume; EF=ejection fraction; SV=stroke volume; CO=cardiac output; CI=cardiac index; SVR=systemic vascular resistance; Ei=time-velocity integral of the mitral inflow velocity waveform representing early filling; Ai= time-velocity integral representing left atrial contraction; Ei/Ai=ratio of Ei to Ai; DT=deceleration time of early mitral inflow velocity; EDWS=LV end-diastolic circumferential wall stress; nt-Pro-BNP=n-terminal-pro brain natriuretic peptide; TNF-α=tumor necrosis factor alpha; IL=interleukin; CRP=C-reactive protein; ROS = level of reactive oxygen species in plasma; RLU = relative light units. All data are Mean±SEM.
p<0.05 vs. baseline;
p<0.05 vs. pre-treatment