Table 2.
Treatment effect (Δ) in untreated heart failure control dogs (HF-CON) (n=7) and in elamipretide-treated heart failure dogs (HF+ELA) (n=7).
| HF-CON | HF+ELA | P-value | |
|---|---|---|---|
| Δ Body weight (kg) | 0.8±0.5 | 0.9±0.3 | 0.87 |
| Δ HR (beats/min) | −3.7±2.1 | 1.7±2.3 | 0.11 |
| Δ mAoP (mmHg) | 0.1±1.6 | −1.3±1.6 | 0.54 |
| Δ LVEDP (mmHg) | 0.6±0.6 | −2.3±0.5 | 0.003 |
| Δ SV (ml) | 2.1±1.5 | 5.3±1.2 | 0.13 |
| Δ CO (L/min) | 0.10±0.14 | 0.48±0.14 | 0.05 |
| Δ CI (L/m2) | 0.1±0.2 | 0.6±0.1 | 0.05 |
| Δ SVR (dynes-sec-cm−5) | −367±285 | −781±228 | 0.28 |
| Δ Ei/Ai | −0.3±0.2 | 0.4±0.7 | 0.36 |
| Δ DT (msec) | −5.7±6.5 | 8.4±5.1 | 0.11 |
| Δ EDWS (gm/cm2) | 0.9±9.0 | −17.6±3.4 | 0.08 |
Abbreviations as in Table 1. All data are Mean±SEM. P-value=probability value between HF-CON and HF+ELA. Values less than 0.05 are considered significant.