Table 3.

Histomorphometric findings at the end of 3 months in normal dogs (n=7), in untreated heart failure control dogs (HF-CON) (n=7) and in heart failure dogs treated with elamipretide (HF+ELA) (n=7).

	VFRF (%)	VFIF (%)	CD (cap/mm2)	ODD (μm)	MCSA (μm2)
Normal	0.0	3.7±0.07	2609±79.5	8.9±0.17	410±10.0
HF-CON	12.3±0.6*	11.8±0.5*	1806±80*	12.6±0.2*	678±5.4*
HF+ELA	11.2±0.9	9.7±0.5†	2026±127†	11.4±0.4†	600±4.3†

Data are shown as Mean ± SEM. VFIF=volume fraction of interstitial fibrosis; VFRF=volume fraction of replacement fibrosis; CD=capillary density; ODD=oxygen diffusion distance; MCSA=myocyte cross-sectional area. All data are Mean±SEM.

^*p<0.05 vs. Normal,

^†p<0.05 vs. HF-CON.