Table 1. Effects of perinatal obesogenic diet consumption on hippocampal-dependent learning and memory.

Only articles containing hippocampal-dependent cognitive tasks were included. M: male, F: female, SD: Sprague Dawley, RD: Research Diets, PND: post-natal day, MWM: Morris Water Maze, HFD: high-fat diet, TFD: trans-fat diet, CD: control diet, TBI: traumatic brain injury

Study	Subjects	Diets	Exposure	Test design	Task	Outcome
Bilbo et al., 2010 [25]	M and F SD rats	RD D12492 60% kcal fat, RD D06061202 60% kcal TFD or RD D12450B 10% kcal fat (control)	Gestation-weaning (PND 21)	Behavior at PND 85-95	MWM	Early life consumption of HFD or TFD caused spatial learning impairments during adulthood despite switching to chow at weaning.
Can et al., 2012 [28]	M SD rats	65% kcal from fat vs 10% kcal from fat (control)	Gestation-(PND119)	Behavior measured in adulthood	MWM	HFD impaired spatial learning
Kuang et al., 2014 [27]	M SD rats	20% sucrose solution + chow or water + chow (control)	Gestational day 1-21	Behavior at 1 and 2 mo. old	MWM	Impaired spatial learning in offspring of high sucrose-fed dams, especially at 1 mo.
Lepinay et al., 2015 [23]	M Wistar rats	HFD (39% kcal from fat) with omega 6:omega 3 fatty acid ratio of 39 or control diet (12% kcal from fat) with omega 6:omega 3 ratio of 5.	Gestation-weaning (PND 21) or Gestation- 5 mo. old	Behavior at 5 months	MWM	Perinatal HFD or exposure from weaning through adulthood had no effect on memory, however animals fed HFD during the perinatal period and post weaning had impaired spatial memory.
Mychasiuk et al., 2015 [30]	M and F SD rats	HFD (60% kcal from fat) + 20% sucrose solution, standard chow and water (control) or caloric restriction on standard chow	Dams exposed 3 wks prior to mating Gestation-PND 47	At PND 30 animals were given mild TBI or sham injury. Behavioral testing PND 35-45.	MWM, Novel Context Mismatch	F offspring on HFD were impaired in novel context mismatch. TBI impaired performance in the novel context mismatch in both standard chow ad libitum and HFD groups, but not in calorically restricted animals.
Page et al., 2014 [26]	M SD rats	RD D12451 45% kcal from fat vs control chow 10 % kcal from fat D12451B	Dams exposed 4 wks prior to mating Gestation-PND 21 or Gestation-PND 118	Behavioral testing during adulthood (PND 110-118)	MWM	Both HFD-HFD and HFD-CD animals were impared in spatial learning compared with CD-CD and CD-HFD.
Peleg-Raibstein et al., 2012 [24]	M and F C57BL/6N mice	HFD (60% kcal from fat) vs standard chow (control).	Dams exposed 3 wks prior to mating Gestation-weaning (PND 21)	Behavioral testing after PND 90	Pavlovian Fear Conditioning	There were no differences in fear conditioning between offspring from HFD-fed and offspring from chow-fed dams.
Tozuka et al., 2010 [21]	M C57BL/6N mice	HFD Clea Japan (57% kcal from fat) vs CE-2 Clea Japan chow (control)	Gestation-lactation d16	Behavioral testing at PND 28 and PND 77	Barnes Maze	Impaired spatial learning in adolescent but not adult mice.
White et al., 2009 [22]	M Long Evans rats	RD D12492 60% kcal fat or RD D12450B 10% kcal fat control.	Dams exposed 4 wks prior to mating Gestation-weaning (PND 21) At 8 wks old, put back on one of the perinatal diets for 9 wks	Behavioral analyses were performed during adulthood (19.5 wks old)	MWM	HFD-HFD animals were impaired in spatial memory retention, but HFD-CD, CD-CD and CD-HFD showed no difference in performance.