Table 2.
Survival fractions (SFs) in different regions and p53 gene statuses using all microscopic extension probability (MEP) models
| MEP model | SF within the beam (%) |
SF in penumbra region (%) |
Total SF (%) |
|||||
|---|---|---|---|---|---|---|---|---|
| mt-p53a (×10−4) | wt-p53b (×10−16) | mt-p53 | wt-p53 | p-value | mt-p53 | wt-p53 | p-value | |
| Circular (2908500/299420)c | 3.68 ± 0.38 | 1.09 ± 0.59 | 6.78 ± 0.82 | 6.45 ± 1.12 | 0.355 | 12.89 ± 0.88 | 12.51 ± 1.22 | 0.352 |
| Elliptical (2511400/125480)c | 4.04 ± 0.40 | 1.16 ± 0.63 | 3.22 ± 0.40 | 3.05 ± 0.54 | 0.349 | 5.49 ± 0.43 | 5.31 ± 0.58 | 0.354 |
| Irregular (2504200/217450)c | 3.75 ± 0.37 | 1.08 ± 0.58 | 5.81 ± 0.68 | 5.51 ± 0.93 | 0.349 | 11.06 ± 0.75 | 10.74 ± 1.01 | 0.351 |
| Exponential (1242100/99864)c | 3.55 ± 0.37 | 0.97 ± 0.52 | 5.51 ± 0.62 | 5.24 ± 0.84 | 0.348 | 14.83 ± 0.85 | 14.31 ± 0.98 | 0.287 |
| Linear (4594200/738690)c | 2.93 ± 0.31 | 0.91 ± 0.49 | 11.26 ± 1.27 | 10.73 ± 1.67 | 0.350 | 29.44 ± 1.39 | 28.84 ± 2.02 | 0.354 |
a
mt-p53: α = 0.17; β = 0.02.
b
wt-p53: α = 0.6; β = 0.06.
c
The numbers in parentheses are the total number of clonogens/the number of clonogens in the penumbra region before treatment for each MEP model.