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. 2014 Sep 5;14(1):21–35. doi: 10.1586/14760584.2015.955478

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Figure 5. — EpiAssembler construction of immunogenic consensus sequences. This figure illustrates the process of assembling highly conserved T-cell epitopes into a single molecule. First, a highly conserved, promiscuous epitope is identified to form the 9-mer core of the ICS peptide (red bar). Overlapping conserved epitopes (pink, orange, green and blue bars) are then added to the N- and C-termini of the peptide until a suitable length is reached for binding in the class II HLA binding groove. This economical approach allows for targeting of multiple strains of a given pathogen using a single peptide, as illustrated by the blended bar at the bottom of the figure.

ICS: Immunogenic consensus sequences.