Table 5.
AD/dementia (n = 17) | % |
Anticholinesterase (e.g., donepezil) | 47.1 |
Memantine | 29.4 |
MS (n = 223) | % |
Interferon beta | 45.3 |
Glatiramer | 27.4 |
Centrally acting muscle relaxants (e.g., baclofen, tizanidine, orphenadrine) | 33.2 |
Urinary antispasmodics (e.g., oxybutynin, tolterodine) | 25.6 |
Psychostimulants (e.g., amphetamine derivatives, modafinil, pemoline) | 18.8 |
Glucocorticoids | 5.8 |
Immunosuppressants (e.g., methotrexate, mycophenolate, azathioprine) | 5.8 |
Mitoxantrone | 4.0 |
4-Aminopyridine | 2.2 |
Stroke/CBVD (n = 51) | % |
Aspirin | 43.1 |
Clopidogrel | 19.6 |
Calcium channel blockers (e.g., dihydropyridine) | 11.8 |
TBI (n = 23) | % |
Topiramate | 13.0 |
Carbamazepine/oxcarbazepine | 13.0 |
Thyroid preparations | 17.4 |
Psychostimulants (e.g., amphetamine derivatives, modafinil, pemoline) | 13.0 |
Antimigraine (e.g., triptans, selective 5HT1 agonists) | 13.0 |
Glucocorticoids | 8.7 |
ALS/MND (n = 199) | % |
Riluzole | 47.7 |
Centrally acting muscle relaxants (e.g., baclofen, tizanidine, orphenadrine) | 31.7 |
Coenzyme Q10 | 31.2 |
Tetracycline antibiotics (e.g., minocycline, doxycycline) | 17.6 |
Creatine | 15.6 |
Beta-2-adrenergic agonists, inhalants | 14.6 |
Beta carotene/vitamin A | 13.1 |
Urinary antispasmodics (e.g., oxybutynin, tolterodine) | 11.1 |
Quinine | 10.6 |
Expectorants and mucolytics (e.g., guaifenesin, n-acetylcysteine) | 9.0 |
Belladonna alkaloids (e.g., atropine, hyocyamine, scopolamine) | 9.0 |
Glycopyrrolate | 7.5 |
PD/movement disorders (n = 23) | % |
Dopamine derivatives (± carbidopa, benserazide, or entacapone) | 65.2 |
Dopamine agonists | 30.4 |
Amantadine | 17.4 |
Selegiline | 8.7 |
Trihexyphenidyl | 0.5 |
Other PBA (n = 17) | % |
Phenytoin | 11.8 |
Tiagabine | 11.8 |
5HT1: type 1 5-hydroxytryptamine (serotonin) receptor; AD: Alzheimer’s disease; ALS: amyotrophic lateral sclerosis; CBVD: cerebrovascular disorders; MND: motor neuron disease; MS: multiple sclerosis; PBA: pseudobulbar affect; PD: Parkinson’s disease; TBI: traumatic brain injury.
aUsed for ≥3 months and taken during the study.