Table II.
Generalized linear mixed model estimating effects of Type D personality on the most relevant EORTC QLQ-C30 and EORTC QLQ-CR38 subscales regarding survivorship over time, mutually adjusted for sociodemographic and clinical characteristics.
| EORTC-QLQ-C30 | EORTC-QLQ-CR38 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Global quality of life Beta and 95% CI |
Fatigue Beta and 95% CI |
Pain Beta and 95% CI |
Insomnia Beta and 95% CI |
Body image Beta and 95% CI |
Future perspective Beta and 95% CI |
Sexual enjoyment Beta and 95% CI |
||||||||
| Sex Female vs. male |
2.0 | 0.8–3.1** | − 3.9 | − 5.5–− 2.3** | − 4.9 | − 6.7–− 3.1** | − 10.7 | − 12.9–− 8.6** | 0.6 | − 1.2–2.3 | 3.7 | 1.8–5.7** | 11.8 | 8.3–15.2** |
| Agea | 0.1 | 0.1–0.2** | − 0.1 | − 0.2–0.01* | − 0.2 | − 0.3–− 0.1** | − 0.1 | − 0.2–− 0.1* | 0.3 | 0.2–0.3** | 0.3 | 0.2–0.4** | − 0.4 | − 0.6–− 0.2** |
| Time since diagnosisa |
0.3 | 0.1–0.5** | − 0.5 | − 0.7–− 0.2** | − 0.3 | − 0.6–0.1 | − 0.4 | − 0.8–− 0.1* | 0.6 | 0.3–0.9** | 1.0 | 0.6–1.3** | 0.1 | − 0.4–0.7 |
| Stage Stage I vs. IV Stage II vs. IV Stage III vs. IV |
− 0.4 − 0.5 0.8 |
− 3.9–3.1 − 4.0–2.9 − 2.6–4.1 |
− 3.9 − 3.6 − 4.4 |
− 8.6–0.8 − 8.2–1.0 − 8.8–0.1 |
− 2.1 − 1.4 − 0.9 |
− 7.3–3.0 − 6.5–3.7 − 5.8–4.0 |
2.2 0.9 2.2 |
− 4.3–8.6 − 5.4–7.2 − 3.9–8.3 |
− 4.8 − 3.9 − 3.2 |
− 9.9–0.4 − 8.9–1.2 − 8.0–1.7 |
12.3 10.7 9.6 |
6.6–18.0** 5.0–16.3** 4.2–15.1** |
− 4.1 − 2.4 − 4.0 |
− 13.5–5.4 − 11.6–6.9 − 12.9–4.9 |
| Chemotherapy yes vs. no |
1.1 | − 0.6–2.7 | − 1.2 | − 3.4–1.0 | 0.9 | − 1.5–3.3 | 0.1 | − 2.9–3.1 | 1.7 | − 0.8–4.0 | 0.3 | − 2.4–3.0 | − 0.6 | − 5.0–3.8 |
| Comorbid conditionsa | − 2.3 | − 2.7–− 2.0** | 2.6 | 2.2–3.0** | 4.0 | 3.5–4.5** | 1.9 | 1.3–2.5** | − 0.6 | − 1.1–− 0.2** | − 1.8 | − 2.4–− 1.3** | 0.1 | − 0.8–1.0 |
| Partner no vs. yes |
0.6 | − 0.7–2.0 | − 1.8 | − 3.6–− 0.1* | − 2.7 | − 4.7–− 0.6* | − 4.6 | − 7.1–− 2.2** | − 0.7 | − 2.7–1.3 | 0.8 | − 1.4–3.1 | 1.6 | − 2.8–6.0 |
| Education High vs. Middle High vs. Low |
0.2 0.1 |
− 1.1–1.5 − 1.7–1.9 |
0.1 − 1.1 |
− 1.7–1.7 − 3.4–1.3 |
0.6 1.1 |
− 1.4–2.5 − 1.5–3.8 |
0.6 − 0.1 |
− 1.8–2.9 − 3.2–3.2 |
1.0 2.3 |
− 0.8–2.8 − 0.1–4.9 |
0.8 1.6 |
− 1.3–3.0 − 1.3–4.6 |
− 0.1 − 3.7 |
− 3.4–3.3 − 8.8–1.5 |
| Time T2 vs. T1 T3 vs. T1 |
− 1.1 − 1.3 |
− 1.9–− 0.3** − 2.2–− 0.4** |
0.2 0.8 |
− 0.8–1.1 − 0.3– 1.8 |
0.7 0.7 |
− 0.5–1.8 − 0.6–1.9 |
− 0.5 0.7 |
− 1.8–0.7 − 0.7–2.2 |
1.1 0.4 |
0.1–2.1* − 0.7–1.5 |
1.5 0.6 |
0.2–2.7* − 0.8–2.0 |
0.4 − 1.1 |
− 1.8–2.5 − 2.5–2.3 |
| Depressiona | − 2.2 | − 2.4–− 2.1** | 2.5 | 2.3–2.7** | 1.7 | 1.5–1.9** | 1.6 | 1.3–1.9** | − 1.8 | − 2.0–− 1.6** | − 2.2 | − 2.5–2.0** | − 1.5 | − 2.0–− 1.1** |
| Type D NA-/SI+ vs. NA-/SI- NA+/SI- vs. NA-/SI- NA+/SI+ vs. NA-/SI- |
− 0.7 − 3.5 − 2.3 |
− 2.3–0.8 − 5.5–− 1.6** − 3.9–− 0.6** |
0.2 5.1 1.8 |
− 1.9–2.3 2.5–7.7** − 0.4–4.0 |
0.4 3.3 0.1 |
− 1.9–2.7 0.5–6.2* − 2.3–2.6 |
0.1 8.0 4.3 |
− 2.8–3.0 4.5–11.6** 1.3–7.3** |
− 1.0 − 6.2 − 4.9 |
− 3.3–1.3 − 9.0–− 3.3** − 7.3–− 2.5** |
− 0.5 − 11.1 − 7.5 |
− 3.1–2.1 − 14.2–− 7.9** − 10.2–− 4.8** |
− 4.7 3.9 − 6.4 |
− 9.0–− 0.5* − 1.5–9.2 − 10.9–− 2.0** |
Only those who completed two or more questionnaires were included in the analyses.
A selection of the EORTC QLQ-C30 and EORTC QLQ-CR38 subscales that are most relevant with respect to survivorship are included in this figure [21].
aContinuous variables are grand-mean centered; *p < 0.05; **p < 0.01.