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. 2015 May 20;9(8):1013–1022. doi: 10.3109/17435390.2014.996192

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© 2015 Crown Copyright. Published by Taylor & Francis.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/Licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — A biological network showing interactions among complement cascade and inflammatory cascade genes/proteins. Red circle: up-regulation, green circle: down-regulation, both red and green: down-regulation of precursor and induction of the activated form. These genes were differentially regulated in this study. No circle: no change in expression or expression levels not measured in this study. Green arrows represent positive regulation/activation, brown arrows represent negative regulation/inhibition and grey arrows represent unspecified regulation. B – binding; C – cleavage; IE – influence on expression; CS – complex subunit; CR – complex group relations.