Table 2.

Within group change scores and between group parameter estimates and p values for cognitive and functional ability over time by RAS medication group.

Cognitive Test	RAS User (mean change ± SD)a	RAS Non User (mean change ± SD)a	RAS user vs non-userb	RAS use * visitc
Trail A	8.1±1.5 p < 0.0001	8.9 ± 2.0 p < 0.0001	−2.6 ± 2.1 p = 0.36	−.27 ± 0.5 p = 0.59
Trail B	35.0 ± 4.2 p < <0.0001	42.0 ± 5.4 p < 0.0001	−5.6 ± 6.2 p = 0.36	−1.2 ± 1.4 p = 0.37
Boston naming	−1.6 ± 0.2 p < 0.0001	−1.4 ± 0.3 p < 0.0001	0.44 ± 0.36 p = 0.22	−.06 ± 0.07 p = 0.39
MMSE	−2.1 ± 0.2 p < 0.0001	−2.6 ± 0.2 p < 0.0001	−.12 ± 0.26 p = 0.63	0.10 ± 0.06 p = 0.13
Logical Memory immediate	−0.3 ± 0.2 p = 0.15	−0.7 ± 0.3 p = 0.0178	−.12 ± 0.37 p = 0.74	0.06 ± 0.08 p = 0.47
Logical Memory delayed	−0.2 ± 0.2 p = 0.49	−0.3 ± 0.3 p = 0.36	0.35 ± 0.41 p = 0.39	−.02 ± 0.08 p = 0.81
Digit Symbol	−4.2 ± 0.5 p < 0.0001	−5.1 ± 0.7 p < 0.0001	1.98 ± 0.92 * p = 0.03	0.00 ± 0.18 p = 0.98
Category fluency (animals)	−1.5 ± 0.3 p < 0.0001	−2.4 ± 0.4 p < 0.0001	0.40 ± 0.40 p = 0.31	0.12 ± 0.09 p = 0.21
Digits forward	−0.2 ± 0.1 p = 0.0405	−0.8 ± 0.1 p < 0.0001	−0.39 ± 0.17 * p = 0.017	0.09 ± 0.04 * p = 0.02
Digits backward	−0.4 ± 0.1 p = 0.0003	−0.5 ± 0.2 p = 0.0007	−0.04 ± 0.17 p = 0.78	0.01 ± 0.04 p = 0.85
CDR-SOB	2.1 ± 0.2 p < 0.0001	2.8 ± 0.2 p < 0.0001	0.11 ± .28 p = 0.70	−.17 ± 0.06 ** p < 0.005

^aWithin group change over time

^bChange in test score over time for RAS uses vs non-users

^cInteraction between time RAS medication use, p<0.005 indicates significant difference in decline per year between RAS users and non-users, a positive coefficient indicates RAS users had higher slope over time for change in test scores than non-RAS users, and a negative coefficient indicates a lower slope over time