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The binding of HLCS to chromatin depends on physical interactions of HLCS with the maintenance DNA methyltransferase DNMT1 and MeCP2. Chromatin-bound HLCS recruits the eukaryotic histone H3 methyltransferase EHMT-1, N-CoR and HDAC. ac, acetylation; bio, biotinylation; HP1, heterochromatin protein 1; me, methylation.
