Figure 1.

Kidney fungal burden (cfu/g of kidney tissue) on day 8 in mice infected with C. glabrata 05-62 and treated with placebo by subcutaneous injection once daily as follows: control (physiological saline); T-2307 at doses of 0.75, 1.5, 3 or 6 mg/kg by subcutaneous injection once daily; or caspofungin at doses of 1 or 10 mg/kg by intraperitoneal injection once daily. Treatment began 1 day post-inoculation and continued for 7 days. Grey circles represent data from the first experiment and black circles represent data from the repeat experiment. Lines represent mean values. *P < 0.001 versus vehicle control; §P < 0.001 versus 1 mg/kg caspofungin. CAS, caspofungin; QD, once daily.