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Aberrant mitosis/cytokinesis in mutant cells bearing Ptptn11D61G mutations. Mitosis and cell division in living Ptpn11+/+ and Ptpn11D61G/D61G MEFs at passage 3–5 were monitored by time-lapse video microscopy, as described in Materials and Methods. Representative cells with abnormal abscission (Upper panel of the Ptpn11D61G/D61G group) and two nuclei (Lower panel of the Ptpn11D61G/D61G group) are shown.
