Table S1.
In vitro IC50 values for 1,2,3-triazole urea inhibitors measured in rat brain homogenate
| Enzyme | KT172 | KT128 | KT185 | KT195 | KML29 |
| DAGLα | 33 | 108 | >10,000 | >50,000 | N/A |
| DAGLβ | 495 | 1,130 | >50,000 | >50,000 | N/A |
| ABHD6 | 18 | 93 | 77 | 54 | >2,000 |
| MAGL | >50,000 | >50,000 | >50,000 | >50,000 | 15 |
| FAAH | >2,000 | >50,000 | >10,000 | 1,075 | >50,000 |
All IC50s were calculated from analysis of ABPP gels and are expressed as nanomolar (nM). Values for KML29 (ABHD6, MAGL, FAAH) have been previously published (1). DAGLα and DAGLβ have not been assessed for KML29 (N/A).