Fig. 4.

Fusion peptide region of HeV F in comparison to PIV5 F. (A) HeV and PIV5 F fusion peptides and preceding regions superimposed. HeV F is shown in light green, and PIV5 F is shown in light orange, with the fusion peptides darkened in HeV F and PIV5 F. Basic protease cleavage site residues are indicated by spheres, and the N- to C-terminal fusion peptide direction is indicated by arrows. (B) Sequence alignment of the fusion peptide regions of HeV, PIV5, and NiV F generated with ClustalW. The basic residue upstream of the N terminus of the fusion peptide is boxed in red, and the remainder of the fusion peptide is darkened. The degree of conservation is indicated as in Fig. 2.