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IM-AA mutation in CaV2.1 channels does not alter spontaneous release in SC-CA1 synapses. (A) Example mEPSCs from WT (black) and IM-AA (red) in the presence of 1 μM ω-conotoxin GVIA and 1 μM tetrodotoxin. (B) Average mEPSC amplitude from WT (black, n = 24) and IM-AA (red, n = 34) (Left), and average mEPSC frequency from WT (black, n = 24) and IM-AA (red, n = 34) (Right). n indicates the number of 4-min recordings in each genotype.
