Table 1. Free Drug Assessment in Serum 16 weeks after DMM.
| Sensor Loading Step | Serum Binding Step | anti-Mouse Binding Step | ||
|---|---|---|---|---|
| Sensor | Biotin ADAMTS-5 Binding (nm Shift) | Serum Sample ID (Mouse # / Treatment) | Serum Binding (nm Shift) | anti-Mouse IgG Binding (nm Shift) |
| A1 | 5.71894 | 1425/IgG2c mAb | 0.10265 | 0.05875 |
| B1 | 5.81748 | 1426/ADAMTS-5 mAb | 2.15856 | 2.39165 |
| C1 | 5.67592 | 1464/No Injection | 0.18539 | 0.04822 |
| D1 | 5.60177 | 1465/No Injection | 0.17637 | 0.04432 |
| E1 | 5.0251 | 1466/ADAMTS-5 mAb | 2.15137 | 2.35766 |
| F1 | 5.46195 | 1467/IgG2c mAb | 0.28938 | 0.03224 |
| G1 | 5.70817 | 1505/ADAMTS-5 mAb | 2.94853 | 1.88211 |
| H1 | 5.61472 | 1507/IgG2c mAb | 0.20515 | 0.04857 |