. Author manuscript; available in PMC: 2017 Feb 1.

Published in final edited form as: Osteoarthritis Cartilage. 2015 Sep 26;24(2):299–306. doi: 10.1016/j.joca.2015.09.005

Table 2. Immunogenicity/Neutralization Assessment of Serum 16 weeks after DMM.

	Sensor Loading Step		Serum Binding Step	ADAMTS-5 Binding Step	anti-Mouse Binding Step
Sensor	mAb Binding (nm Shift)	Serum Sample ID (Mouse # / Treatment)	Serum Binding (nm Shift)	ADAMTS-5 Binding (nm Shift)	anti-Mouse IgG Binding (nm Shift)
A1	4.56144	1425/IgG2c mAb	0.7295	2.07617	1.65979
B1	4.47963	1426/ADAMTS-5 mAb	0.48773	2.21794	1.67662
C1	4.71362	1464/No Injection	0.38654	2.3458	1.69864
D1	4.633	1465/No Injection	1.10738	2.03582	1.49423
E1	4.72779	1466/ADAMTS-5 mAb	0.47894	2.21242	1.64249
F1	4.67933	1467/IgG2c mAb	0.67129	2.18379	1.56537
G1	4.47408	1505/ADAMTS-5 mAb	0.89388	2.01044	1.60488
H1	4.54082	1507/IgG2c mAb	0.65863	2.09008	1.64701