Table 2. The effect of CLM, FCLM, and xenical administration on histological and blood biochemical parameters in the mouse model of HFD-induced obesity.
| Experimental groups | |||||
|---|---|---|---|---|---|
| Parameters | ND | HD | HCLM | HFCLM | HX |
| Weight of tissues | |||||
| Subcutaneous fat (g) | 0.33±0.02 | 1.59±0.04# | 1.00±0.09*** | 1.03±0.13*** | 0.90±0.09*** |
| Adipose tissue | |||||
| Adipocyte area (μm) | 49.40±1.65 | 128.20±1.83# | 77.10±0.77*** | 70.30±1.08*** | 76.50±1.22*** |
| Epididymal adipose tissue (g) | 0.66±0.05 | 2.72±0.06# | 1.81±0.11*** | 1.85±0.23** | 1.68±0.10*** |
| Adipose tissue (g) | 0.23±0.03 | 1.11±0.03# | 0.83±0.06*** | 0.84±0.10* | 0.75±0.05*** |
| Biochemical parameters | |||||
| Total cholesterol (mg/dL) | 157.30±13.34 | 214.30±9.89# | 192.00±5.69* | 200.60±10.31 | 201.40±5.63 |
| Triacylglycerol (mg/dL) | 97.60±7.05 | 193.90±19.50# | 89.90±6.63*** | 91.60±5.85*** | 107.80±3.07*** |
| LDL-cholesterol (mg/dL) | 30.60±2.89 | 36.40±5.97 | 31.10±2.09 | 31.80±1.87 | 28.90±3.25 |
| HDL-cholesterol (mg/dL) | 84.90±3.23 | 104.90±3.16# | 104.30±3.63 | 109.00±4.09 | 86.00±1.71*** |
| Glucose (mg/dL) | 131.10±13.60 | 204.70±12.25# | 196.10±13.01 | 202.90±10.70 | 188.70±13.28 |
| ALT (U/L) | 29.80±1.85 | 41.60±1.54# | 25.60±1.35*** | 29.50±1.79*** | 33.70±2.06** |
| Insulin (ng/ml) | 2935.60±339.10 | 3466.20±427.50# | 2370.60±227.00* | 3001.20±217.40 | 2472.55±193.50* |
| Leptin (ng/ml) | 0.23±0.05 | 1.10±0.27# | 0.37±0.08* | 0.85±0.15 | 0.47±0.22* |
The statistical analysis was performed by an independent t test in comparison with the HD group (#p value < 0.05, *p value < 0.05, **p value < 0.01, ***p value < 0.001).
ND (normal-diet group), HD (high-fat diet group), HCLM (HFD with CLM administrated group), HFCLM (HFD with FCLM administrated group), HX (HFD with xenical administrated group).