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. Author manuscript; available in PMC: 2016 Feb 5.
Published in final edited form as: Nat Rev Nephrol. 2014 Dec 9;11(2):113–123. doi: 10.1038/nrneph.2014.219

Figure 2.

Figure 2

Molecular structure of bovine UT-B. a | Top view of the extracellular face of the bovine UT-B homotrimer. Monomers are labelled 1–3. Based on the X-ray crystal structure data (Protein Data Bank ID 4EZD).26 b | Structure of a bovine UT-B monomer viewed from its side, with the position of the membrane approximated, and with two co-crystallized selenourea molecules indicated in spherical form at the putative urea binding sites (arrowheads). c | Magnified view of a UT-B monomer and narrow channel surface. The co-crystallized selenourea molecules (arrowheads) are depicted interacting through hydrogen bonds with Asn227 at the S0 site and Asn63 at the Si site. Thr334 and Thr172 form the narrow Sm constriction at the centre of the channel. Abbreviations: P, tilted helix; T, transmembrane helix.