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. Author manuscript; available in PMC: 2016 Feb 5.
Published in final edited form as: Nat Rev Nephrol. 2014 Dec 9;11(2):113–123. doi: 10.1038/nrneph.2014.219

Figure 6.

Figure 6

Small-molecule inhibitors of UT-A. a | The chemical structure of UTA inh-A1 and the chemical structure of UTAinh-E02. b | Concentration–inhibition data for UTAinh-A1 inhibition of UT-A1 and UT-B urea transport. UT-A1 inhibition exhibits an IC50 of 1–2 μM, approximately 100-fold higher than the IC50 it exhibits for UT-B inhibition. Abbreviations: inh, inhibitor; UT, urea transporter. Permission for part b obtained from the Federation of American Societies for Experimental Biology © Esteva-Font, C. et al. FASEB J. 28, 3878–3890 (2014).