. 2016 Feb 5;11(2):e0148765. doi: 10.1371/journal.pone.0148765

Table 4. Instrumental Variable analysis using 2SLS.

Lipids	N	Predicted alcohol consumption quartiles^†	β^*	95% CI		p^a	p overall^b	1^st-stage partial R²	1^st-stage F-value
TG ^¥	9,911	q1	0.00				<0.001	0.12%	12.17
		q2	-0.06	-0.09	-0.02	0.001
		q3	-0.13	-0.20	-0.07	<0.001
		q4	-0.08	-0.17	0.00	0.049
Total cholesterol	9,751	q1	0.00				<0.001	0.11%	10.86
		q2	-5.54	-8.23	-2.85	<0.001
		q3	-7.71	-13.26	-2.15	0.007
		q4	-4.56	-11.36	2.25	0.189
HDL-c ^¥	10,132	q1	0.00				0.117	0.13%	13.48
		q2	0.01	-0.01	0.03	0.435
		q3	0.04	0.00	0.07	0.070
		q4	0.03	-0.02	0.07	0.293
HDL2-c ^¥	10,120	q1	0.00				<0.001	0.13%	13.48
		q2	0.04	0.00	0.07	0.040
		q3	0.10	0.03	0.17	0.007
		q4	0.06	-0.03	0.15	0.179
HDL3-c	10,120	q1	0.00				0.916	0.13%	13.48
		q2	-0.19	-0.87	0.49	0.580
		q3	0.08	-1.23	1.38	0.908
		q4	0.11	-1.51	1.74	0.892
LDL-c	9,751	q1	0.00				<0.001	0.11%	10.86
		q2	-4.60	-7.18	-2.03	<0.001
		q3	-6.87	-12.24	-1.50	0.012
		q4	-4.57	-11.11	1.96	0.170
sdLDL-c ^¥^#	8,102	q1	0.00				0.054	0.07%	6.00
		q2	-0.04	-0.08	-0.01	0.014
		q3	-0.08	-0.15	-0.005	0.037
		q4	-0.08	-0.17	0.01	0.067
apoB ^¥^#	7,663	q1	0.00				0.022	0.08%	6.13
		q2	-0.03	-0.04	-0.01	0.005
		q3	-0.04	-0.07	0.001	0.058
		q4	-0.04	-0.08	0.01	0.132
Lp(a) ^¥	9,924	q1	0.00				0.578	0.14%	13.87
		q2	-0.02	-0.09	0.06	0.657
		q3	-0.05	-0.20	0.10	0.500
		q4	-0.01	-0.20	0.18	0.890

^†Quartile 1: 1.49–3.63 g/wk, quartile 2: 3.63–4.66 g/wk, quartile 3: 4.66–10.57 g/wk, and quartile 4: 10.57–19.54 g/wk,

*second stage regression coefficient between lipid measures and predicted alcohol consumption quartiles with quartile 1 as the reference group,

^aWald p-value comparing each quartile with the quartile 1,

^bWald p-value for overall effect of alcohol consumption,

^¥ ln transformed,

^# measured at visit 4