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. Author manuscript; available in PMC: 2016 May 30.
Published in final edited form as: Nat Biotechnol. 2015 Nov 30;34(2):155–163. doi: 10.1038/nbt.3391

Figure 2. Lineage landscape of hotspot mutations.

Figure 2

a) Both common and rare hotspots are largely disseminated across a broad range of malignancies. All hotspots detected in genes with at least one hotspot affecting >5% of tumors of one or more tumor types are shown. Novel hotspots are bolded blue. Genes are grouped broadly by functional similarity, hotspots are ordered by amino acid position, and tumor types (columns, labeled at bottom) are sorted according to the fraction of tumors affected by 1 or more hotspots overall (panel B). The percent of samples altered is represented by colored squares and indicated text. Hotspots in tumor suppressors TP53, PTEN, APC, and FBXW7 were excluded here (see Supplementary Fig. 5). b) The fraction of tumors of a given type (as indicated) affected by one or more hotspots. Black circles represent the median mutation rate (right axis) in the indicated tumor type (bar is the median absolute deviation). Shown at top is the number of tumors of each type with a hotspot mutation affecting a known or candidate oncogene1.