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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Diabetologia. 2015 Dec 15;59(3):481–491. doi: 10.1007/s00125-015-3835-x

Fig. 2. Relationship between GRS12 and HDL-C levels, HOMA-B, HOMA-IR and prevalence of type 2 diabetes in Pima Indians.

Fig. 2

GRS calculated as number of risk alleles and plotted to include reasonable number of participants in each category. (a) Association with HDL-C (p=1.4 × 10 −47, effect= −2.2%). (b) Association with HOMA-B (p=0.21). (c) Association with HOMA-IR (p=0.003, β [SD units]=0.01). (d) Association with predicted diabetes probability (p=0.04, OR 1.03 [1.00, 1.05]), diabetes association NS when rs4731702 and rs1800961 are removed from GRS12. Error bar, SEM. T2D, type 2 diabetes