GRS calculated as number of risk alleles and plotted to include reasonable number of participants in each category. (a) Association with HDL-C (p=1.4 × 10 −47, effect= −2.2%). (b) Association with HOMA-B (p=0.21). (c) Association with HOMA-IR (p=0.003, β [SD units]=0.01). (d) Association with predicted diabetes probability (p=0.04, OR 1.03 [1.00, 1.05]), diabetes association NS when rs4731702 and rs1800961 are removed from GRS12. Error bar, SEM. T2D, type 2 diabetes