Table 3.
Association of HDL-C-associated SNPs with type 2 diabetes in Pima Indians from the Gila River Indian Community
|
|
|
|
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|---|---|---|---|---|---|---|---|---|
| SNP ID | Locusa | Combined participants (N=7,710) |
Male participants (n = 3,426) |
Female participants (n = 4,284) |
||||
| OR (95% CI) |
p
value |
p_int_sex | OR (95% CI) | p value | OR (95% CI) | p value | ||
|
|
|
|
||||||
| rs172315 06 |
CETP | 1.03 (0.94, 1.13) |
0.54 | 0.66 | ||||
| rs127209 22 |
CETP | 1.12 (1.02, 1.24) |
0.02 | 0.004 | 0.98 (0.86, 1.14) |
0.81 | 1.25 (1.11, 1.43) |
2.4×10−4 |
| rs563229 06 |
DOCK6 | 1.04 (0.95, 1.14) |
0.38 | 0.27 | ||||
| rs998728 9 |
PPP1R3B | 0.96 (0.87, 1.07) |
0.48 | 0.43 | ||||
| rs188302 5 |
ABCA1 | 0.95 (0.87, 1.04) |
0.28 | 0.01 | 1.08 (0.94, 1.24) |
0.28 | 0.85 (0.76, 0.96) |
9.6×10−3 |
| rs153208 5 |
LIPC | 1.01 (0.92, 1.10) |
0.89 | 0.42 | ||||
| rs838880 | SCARB1 | 0.99 (0.90, 1.08) |
0.78 | 0.77 | ||||
| rs473170 2 |
KLF14 | 1.14 (1.04, 1.25) |
3.5×10 −3 |
0.06 | 1.06 (0.93, 1.21) |
0.40 | 1.25 (1.10, 1.40) |
3.2×10−4 |
| rs713459 4 |
MMAB | 1.11 (1.01, 1.22) |
0.03 | 0.43 | ||||
| rs107783 4 |
LIPC | 0.99 (0.88, 1.11) |
0.81 | 0.19 | ||||
| rs101277 75 |
GALNT2 | 0.90 (0.83, 0.99) |
0.03 | 0.89 | ||||
| rs180096 1 |
HNF4A | 1.38 (1.09, 1.75) |
7.6×10 −3 |
0.006 | 0.91 (0.62, 1.33) |
0.63 | 1.83 (1.35, 2.46) |
7.7×10−5 |
HDL-C associated SNPs were analysed for association with type 2 diabetes in the entire data set of 7,710 Pima Indian participants. SNPs showing evidence of sex interaction (p_int_sex approaching or less than 0.05) for type 2 diabetes association were further analysed separately in male and female participants. ORs are reported per copy of the HDL-C-lowering allele
a
Locus is based on previously reported data [7] or the closest plausible candidate gene