Table 4.
Association of SNPs in CETP, KLF14 and HNF4A with type 2 diabetes before and after adjustment for HDL-C
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| SNP ID | Locus | Type 2 diabetesa (n=5,494) | Type 2 diabetes_adjHDL-Cb (n=5,494) | ||||||
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| Male participants (n=2,296) | Female participants (n=3,198) |
Male participants (n=2,296) | Female participants (n=3,198) |
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| OR (95% CI) | p value | OR (95% CI) |
p value | OR (95% CI) | p value | OR (95% CI) |
p
value |
||
| rs1272092 2 |
CETP | 0.97 (0.83, 1.14) | 0.72 | 1.31 (1.14, 1.50) |
8.5×10−5 | 0.86 (0.75, 1.05) | 0.15 | 1.20 (1.05, 1.38) |
8.0×10 −3 |
| rs4731702 | KLF14 | 1.01 (0.87, 1.17) | 0.88 | 1.23 (1.07, 1.40) |
2.8×10−3 | 0.97 (0.83, 1.12) | 0.66 | 1.21 (1.06, 1.39) |
5.1×10 −3 |
| rs1800961 |
HNF4
A |
0.83 (0.53, 1.30) | 0.42 | 1.62 (1.16, 2.26) |
4.5×10−3 | 0.81 (0.52, 1.27) | 0.37 | 1.57 (1.12, 2.20) |
8.3×10 −3 |
Type 2 diabetes association was analysed in the subset of samples (n=5,494) informative for both HDL-C levels and type 2 diabetes status. Analysis is shown separately in male and female participants. ORs reported are per copy of the HDL-C-lowering allele
a
Type 2 diabetes association before adjustment for HDL-C
b
Type 2 diabetes association after adjustment for HDL-C