Table 5.
Association of SNPs in CETP with HDL-C and type 2 diabetes in full-heritage Pima Indians from the Gila River Indian Community
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| SNP ID | Alleles | HDL-C | Type 2 diabetes | |||||||
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| Full-Pima participants (n=2,717) |
Full-Pima participants (n=3,625) |
Full-Pima male participants (n=1,553) |
Full-Pima female participants (n=2,072) |
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| R/NR | RAF | Effect (%) |
p value | OR (95% CI) | p value | OR (95% CI)d | p value | OR (95% CI)d |
p value | |
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| rs17231506 | C/T | 0.67 | −6.9 | 2.6×10 −18 |
1.00 (0.88, 1.13) | 0.97 | 1.04 (0.87, 1.23) |
0.70 | 0.98 (0.83, 1.15) |
0.79 |
| rs12720922 | A/G | 0.33 | −6.4 | 1.9×10 −17 |
1.16 (1.03, 1.30) | 0.01 | 1.01 (0.85, 1.20) |
0.91 | 1.32 (1.12, 1.54) |
5.0×10−4 |
| rs289713 | T/A | 0.58 | −6.3 | 4.7×10 −17 |
1.08 (0.96, 1.22) | 0.20 | 1.05 (0.89, 1.25) |
0.56 | 1.11 (0.95, 1.30) |
0.17 |
| rs708272 | G/A | 0.43 | −5.8 | 2.2×10 −15 |
1.11 (0.99, 1.24) | 0.08 | 1.01 (0.86, 1.19) |
0.94 | 1.22 (1.04, 1.41) |
0.01 |
| rs6499863 | T/C | 0.27 | −5.4 | 5.6×10 −11 |
1.26 (1.11, 1.43) | 4.6×10−
4 |
1.08 (0.90, 1.31) |
0.41 | 1.44 (1.21, 1.71) |
2.8×10−5 |
| rs289742 | C/G | 0.78 | −4.0 | 1.4×10 −5 |
1.02 (0.88, 1.18) | 0.78 | 0.90 (0.74, 1.10) |
0.31 | 1.15 (0.94, 1.39) |
0.18 |
| rs1800774 | T/C | 0.40 | −3.2 | 2.5×10 −5 |
1.05 (0.94, 1.19) | 0.39 | 0.96 (0.80, 1.15) |
0.69 | 1.14 (0.97, 1.32) |
0.12 |
| rs5882 | A/G | 0.47 | −2.9 | 1.4×10 −4 |
1.04 (0.92, 1.17) | 0.53 | 0.93 (0.78, 1.11) |
0.43 | 1.14 (0.98, 1.33) |
0.09 |
| rs5880 | G/C | 0.08 | −5.3 | 3.2×10−4 | 0.80 (0.65, 0.99) | 0.04 | 0.68 (0.48, 0.97) |
0.03 | 0.89 (0.69, 1.15) |
0.37 |
| rs708273 | C/T | 0.93 | −2.0 | 0.16 | 1.13 (0.89, 1.44) | 0.31 | 1.16 (0.81, 1.67) |
0.41 | 1.12 (0.83, 1.52) |
0.45 |
| rs820299 | T/C | 0.91 | −1.4 | 0.28 | 1.07 (0.87, 1.33) | 0.52 | 0.96 (0.70, 1.32) |
0.80 | 1.17 (0.90, 1.53) |
0.24 |
| rs8045701 | T/C | 0.69 | −0.3 | 0.74 | 1.03 (0.91, 1.17) |
0.66 | 1.01 (0.83, 1.22) |
0.95 | 1.05 (0.83, 1.23) | 0.59 |
| rs291044 | G/A | 0.93 | −0.4 | 0.76 | 1.10 (0.87, 1.39) | 0.43 | 1.23 (0.79, 1.75) |
0.25 | 0.99 (0.74, 1.35) |
0.97 |
| rs12708970 | G/T | 0.77 | −0.3 | 0.77 | 1.11 (0.97, 1.29) | 0.14 | 1.02 (0.82, 1.27) |
0.85 | 1.20 (1.01, 1.44) |
0.04 |
Type 2 diabetes association results are presented both separately in male and female participants and in the combined sample of full-heritage Pima Indians. HDL-C values were log transformed for calculating p value and effect estimates. Effect is given as percentage reduction per copy of the risk allele. ORs are given per copy of the HDL-C-lowering allele
NR, non-risk allele; R, risk allele (HDL-C-lowering allele); RAF, risk allele frequency in Pima Indians