Fig 5.
The grape diet significantly protected the retina from oxidative stress. ERG was used to quantify retinal function after injury. The a-waves, representing photoreceptor responses, and b-waves, representing inner retina responses, are shown. The intensity of light stimulation in log cd-s/m2 is indicated on the x-axis. Oxidative injury led to reduced a- (A) and b- (B) wave amplitudes in mice on the control diet (light and dark green bars), compared with saline injected eyes. In contrast, ERG responses in mice on the grape diet were equivalent between paraquat-injury and saline control (light and dark purple bars), indicating preserved retina function. Furthermore, the b-wave amplitudes of paraquat-injected mice on the grape diet were significantly higher than paraquat-injected mice on the control diet (n=8 (PQ), n=5 (saline), *p<0.05). Mean ± SE shown.