Figure 1. Macrophage dynamics during angiogenesis and lymphangiogenesis.
Macrophages exhibit a variety of dynamic cell behaviors, including phagocytosis, trafficking, differentiation, proliferation, and secretion of growth factors, enzymes, and chemokines, that are potentially important to the growth and remodeling of the microvasculature during angiogenesis and lymphangiogenesis. The common dynamics implicates macrophages as an attractive cellular target for therapies pro- and against both processes a cellular link that can be targeted.