A, Representative image of a BALB/c mouse after placement
of a single AC (1AC) on the proximal portion of the femoral artery, immediately
proximal to the epigastric arterial branch. Arrow indicates site of constrictor
placement. 1 Femoral artery. 2 Lateral Circumflex Femoral. 3 Superficial caudal
epigastric artery. B, Representative gross anatomy photos and
photomicrographs of TA muscle from BALB/c and BL6 mice subjected to subacute
femoral artery occlusion via the placement of a single AC on the proximal
femoral artery (1AC) for 15-days. C, Representative images from
laser Doppler perfusion imaging in BALB/c and BL6 mice before and after 1AC
placement up to 28 days post-operatively. D, Quantitation of paw
perfusion in BALB/c (N=29) and BL6 (N=27) mice, represented as a ratio of
ischemic (L) to non-ischemic (R) limb perfusion. *
P<0.05 vs. day and ischemic model matched BL6.