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Intracellular GRN controlling the differentiation of the ICM into Epi and PrE. Gata6 and Nanog inhibit each other and self-activate. Fgf/Erk signaling, which is activated through the binding of Fgf4 to the receptor FGFR2, activates Gata6 and inhibits Nanog. The synthesis of the receptor FGFR2 is activated by Gata6 and inhibited by Nanog. The extracellular concentration of Fgf4 perceived by the cell (Fp) is considered as a control parameter (redrawn from our previous work (6)).
