Figure 8.

Behavior of the model with internal noise compared to that with external noise. (A) Statistics of the final outcomes of the stochastic simulations with Gillespie’s algorithm in the absence of variability on Fgf4 (γ_i = 0 for all cells), where medium gray indicates the average number of cells in the PrE state, light gray the average number of cells in the Epi state, white the average number of cells in the ICM state, and dark gray the average number of cells that switch at least once from Epi to PrE or vice versa during the simulation (100 arbitrary time units). (B) Statistics of the time spent in the ICM state in the same conditions as in (A). The cells are considered to be in the ICM state as long as |G_i − N_i| < 1.2. (C) Statistics of the final outcomes of deterministic simulations including variability on Fgf4 (γ_i randomly chosen in the (−γ, + γ%) interval for each cell of the population). The color code is the same as in (A). (D) Statistics of the time spent in the ICM state in the same conditions as in (C). For all graphs, parameter values are given in Table S1 and initial conditions are as in Fig. 4.