Figure 2.

Simulation of a glucose-stimulated β-cell using the DOM in its original form (i.e., with $k_{\text{PDH}}^{Ca}=0$ in Eq. 2). All parameter values are as previously published corresponding to Fig. 1A in Watts et al. (25) with the exception of $g_{K\left(Ca\right)}$ = 200 pS. (A) In contrast with experimental observation, PKAR and Perceval exhibit a sustained rise throughout the active phase. (B) Metabolic fluxes and time derivatives; $d\left[\text{FBP}\right]/dt$ has the same sign as $J_{\text{PFK}}-J_{\text{PDH}}/2$ and $d\left[\text{ATP}\right]/dt$ has the same sign as $J_{\text{ANT}}-J_{\text{hyd}}.$ (C) Model schematic of metabolic fluxes.