Figure 3.
Simulation of a glucose-stimulated β-cell using the modified DOM. Modifying the effects of Ca2+ provides agreement with experimental data. Parameter values for this and the following figures, unless otherwise specified, are listed in Table S1 in the Supporting Material. (A) PKAR and Perceval have a peak at the beginning of the active phase and a nadir near the end of the active phase. (B) Metabolic fluxes and time derivatives; has the same sign as and has the same sign as (C) Model schematic of metabolic fluxes. In contrast to Fig. 2, Ca2+-activation of PDH is incorporated and Ca2+ inhibition of mitochondrial ATP production is neglected.