Figure 5. Calcium signaling in NPC disease.
(A) Human fibroblasts derived from healthy subjects (control, 25 cells) or patients with Niemann Pick disease type C (NPC, 31 cells) were loaded with 5 µM Sph-Cou (1) and uncaged for 3s as indicated. Traces represent mean values with the standard error of the mean plotted as error bars. (B) Histograms showing the distribution of the maximum observed amplitude compared to baseline of all cells with the response threshold set to 10% increase over baseline.